Evidence was found from the Neolithic and Early Minoan period proving the habitation of the village in this early period. After the fall of Knossos, Gortys was the ruling city of Crete. Lentas is known as one of his harbors. In was under the ruling of Gortys that the sanctuary of Asklepios was established. More specific in the 4 th century B.C. In 46 B.C. Lentas was completely destroyed by a tremendous earthquake and only partly rebuilt.
During the Roman occupation the Asklepios became s sanitarium where sick, wealthy Romans were treated. The treatment consisted of a diet with mineral water from an ancient spring near the temple of Asklepios. The water was believed to have therapeutic, healing effects.